IMIDACLOPRID

Common name: Imidacloprid

Chemical name: 1-[(6-chloro-3-pyridinyl)methyl]- N -nitro-2-imidazolidinimine

Structural formula:

Chemical class: Pyridylmethylamine insecticide

CAS No.: 138261-41-3

Properties: Technical product is white to yellowish powder. M.p. 144 ℃ . V.p. 4 × 10 -7 mPa (20 ℃ ). Soluble in water 0.61g/L (20 ℃ ). In dichloromethane 55, isopropanol 1.2, toluene 0.68, n-hexane ﹤ 0.1 (all in g/L, 20 ℃ ). Stable to hydrolysis at pH 5-11

Toxicity: Acute oral LD 50 for male and female rats c. 450, mice c. 150 mg/kg. Acute percutaneous LD 50 (24 h) for rats ﹥ 5000 mg/kg. Non-irritating to eyes and skin (rabbits). Not a skin sensitiser. Inhalational, LC 50 (4 h) for rats ﹥ 5323 mg/m 3 dust, 69 mg/m 3 air (aerosol).

Ecotoxicology: Birds, acute oral LD 50 for bobwhite quail 152 mg/kg. Dietary LC 50 (5 d) for bobwhite quail 2225, mallard duck ﹥ 5000 mg/kg. Fish, LC 50 (96 h) for golden orfe 237, rainbow trout 211 mg/L. Bees, Harmful to honeybees by direct contact, but no problems expected when not sprayed into flowering crop or when used as a seed treatment. Worms, LC 50 for Eisenia foetida 10.7 mg/kg dry soil. Daphnia, LC 50 (48 h) 85 mg/L.

Environmental fate: Animals, after oral administration of methylene-C 14 - and 4,5-imidazolidine-C 14 - labeled imidacloprid to rats, the radioactivity was quickly and almost completely absorbed from the gastro-intestinal tract and quickly eliminated (96% within 48 hours, mainly via the urined). Only c. 15% was eliminated as unchanged parent compound; the most important metabolic steps were hydroxylation at the imidazolidine ring, hydrolysisto 6-chloronicotinic acid, loss of the nitro group with formation of the guanidine and conjugation of the 6-chloronicotinic acid with glycine. All metabolites found in the edible organs and tissues of farm animals contained the 6-chloronicotinic acid moiety. Imidacloprid is also quickly largely eliminated from hens and goats. Plants, metabolism was investigated on rice (after soil treatment), maize (seed treatment), potatoes (granule or spray application), aubergines (granules) and tomatoes (spray treatment) In all cases, imidacloprid is metabolized by loss of the nitro group, hydroxylation at the imidazolidine ring, hydrolysis to 6-chloronicotinic acid and formation of conjugates; all metabolites contained the 6-chloropyridinylmethylene moiety. Soil/Environment, in lab. studies, the most important metabolic steps were oxidation at the imidazolidine ring, reduction or loss of the nitro group, hydrolysis to 6-chloronicotinic acid and mineralisation; these processes were strongly accelerated by vegetation. Imidacloprid shows a medium adsorption to soil. Column leaching tests (with prior ageing) with a.i. and various formulations showed that imidacloprid and soil metabolites are to be classified as immobile; leaching into deeper soil layers is not to be expected if imidacloprid is used as recommended. Stable to hydrolysis under sterile conditions (under exclusion of light). Environmental DT 50 c. 4 h (calc., based on tests of direct photolysis in aqueous solutions). Besides sunlight, the microbial activity of a water/sediment system is an important factor for the degradation of imidacloprid.

Treatment: Symptomatic treatment.

Mode of action: Systemic insecticide with contact and stomach action. Readily taken up by the plant and further distributed acropetally, with good root-systemic action.

Usage: Control of sucking insects, including ricehoppers, aphids, thrips and whiteflies. Also effective against soil insects, termites and some species of biting insects, such as rice water weevil and Colorado beetle. Has no effect on nematodes and spider mites. Used as a seed dressing, as soil treatment and as foliar treatment in different crops, e.g. rice, cotton, cereals, maize, sugar beet, potatoes, vegetables, citrus fruit, pome fruit and stone fruit.