IMAZALIL

Common name: Imazalil

Chemical name: ( RS )-1-(β-allyloxy-2,4-dichlorophenylethyl)imidazole
or
allyl ( RS )-1-(2,4-dichlorophenyl)-2-imidazol-1-ylethyl ether

Structural formula:

Chemical class: Azole fungicide

CAS No.: 35554-44-0

Properties: Technical product is slightly yellow to brown powder. M.p. 52.7 ℃ . B.p. ﹥ 340 ℃ . V.p. 0.158 mPa (20 ℃ ). Soluble in water 0.18 g/L (pH 7.6, 20 ℃ ). In acetone, dichloromethane, ethanol, methanol, isopropanol, xylene, toluene, benzene ﹥ 500, hexane 19 (all in g/L, 20 ℃ ). Also soluble in heptane and petroleum ether.

Toxicity: Acute oral LD 50 for rats 227-343, dogs ﹥ 640mg/kg. Acute percutaneous LD 50 for rats 4200-4880 mg/kg. Inhalational, LC 50 (4 h) for rats 16 mg/L air (with 200g/L EC).

Ecotoxicology: Birds, LD 50 for ring-necked pheasant 2000 mg/kg. LC 50 (8 d) for mallard ducks ﹥ 2510 mg/kg b.w. Fish, LC 50 (96 h) for rainbow trout 1.5, bluegill sunfish 4.04 mg/L. Bees, not hazardous to bees when used as directed. LD 50 (oral) 40 μ g/bee. Daphnia, LC 50 (48 h) 3.5 mg/L.

Environmental fate: Animals, in rats, following oral administration, 90% is eliminated in the metabolized form within 4 days. Plants, in plants, imazalil is transformed into α -(2,4-dichlorophenyl)-1H-imidazole-1-ethanol. Soil/Environment, DT 50 30-170 d. Soil adsorption K 182 (clay loam), 209 (sandy loam), 68 (sandy soil).

Treatment: Get medical aid. Eyes, flush with plenty of water. Skin, wash with soap and water. Inhalation, remove to fresh air. Apply artificial respiration if needed. Ingestion, drink a large quantity of milk, egg white, gelatin solution or if these are not available, large quantities of water. Avoid alcohol. Never give anything by mouth to an unconscious person.

Mode of action: Systemic fungicide, with protective and curative action.

Usage: Control of a wide range of fungal diseases on fruit, vegetables, and ornamentals, e.g. powdery mildews on cucurbits and ornamentals; powdery mildew on roses; storage diseases (particularly Penicillium, Gloeosporium, Phomopsis, Phoma spp., etc) of citrus fruit, pome fruit, bananas, and seed potatoes. Also used as a seed dressing, for control of diseases (particularly Fusarium and Helminthosporium spp.) of cereals.